Biologically Active Small Molecules

An inhibitor of PARP (IC₅₀ = 180 nM) blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of &gamma-radiation, although it is not cytotoxic in the absence of radiation.

An inhibitor of PARP (IC₅₀ = 180 nM) blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of &gamma-radiation, although it is not cytotoxic in the absence of radiation.

An inhibitor of PARP (IC₅₀ = 180 nM) blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of &gamma-radiation, although it is not cytotoxic in the absence of radiation.

An intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi metabolized by a variety of enzymes in mammals, including N-acetyltransferases may also be utilized by bacteria or fungi that

An intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi metabolized by a variety of enzymes in mammals, including N-acetyltransferases may also be utilized by bacteria or fungi that

An intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi metabolized by a variety of enzymes in mammals, including N-acetyltransferases may also be utilized by bacteria or fungi that

An intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi metabolized by a variety of enzymes in mammals, including N-acetyltransferases may also be utilized by bacteria or fungi that

An ABAH that specifically and irreversibly inhibits the peroxidation activity of myeloperoxidase (IC₅₀ = 0.3 &muM) can be used with enzyme preparations, in cell cultures, and also in vivo.

An ABAH that specifically and irreversibly inhibits the peroxidation activity of myeloperoxidase (IC₅₀ = 0.3 &muM) can be used with enzyme preparations, in cell cultures, and also in vivo.

4-Aminomethylindole is a synthetic intermediate useful for pharmaceutical synthesis.

4-Aminomethylindole is a synthetic intermediate useful for pharmaceutical synthesis.

4-Aminomethylindole is a synthetic intermediate useful for pharmaceutical synthesis.