Biologically Active Small Molecules

5-(2-Aminopyridyl)amide oxime is a synthetic intermediate useful for pharmaceutical synthesis.

5-(2-Aminopyridyl)amide oxime is a synthetic intermediate useful for pharmaceutical synthesis.

A modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA used to quantify DNA hydroxymethylation levels in biological samples.

A modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA used to quantify DNA hydroxymethylation levels in biological samples.

A modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA used to quantify DNA hydroxymethylation levels in biological samples.

A modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA used to quantify DNA hydroxymethylation levels in biological samples.

An inhibitor of NHE1, NHE2, and NHE3 (Kis = 0.02, 0.25, and 14 &muM, respectively).

An inhibitor of NHE1, NHE2, and NHE3 (Kis = 0.02, 0.25, and 14 &muM, respectively).

A potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 &muM, respectively less effectively inhibits NHE4 (IC₅₀ &ge10 &muM).

A potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 &muM, respectively less effectively inhibits NHE4 (IC₅₀ &ge10 &muM).

A potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 &muM, respectively less effectively inhibits NHE4 (IC₅₀ &ge10 &muM).

A precursor in the biosynthesis of porphyrins used in photodynamic therapy for a range of dermatological conditions, cancers, and other diseases also used in fluorescence-based identification of tumor tissue for accurate resection of diseased