Biologically Active Small Molecules

A thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity used as a chemotherapeutic for acute leukemia and other types of cancer,

A thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity used as a chemotherapeutic for acute leukemia and other types of cancer,

A thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity used as a chemotherapeutic for acute leukemia and other types of cancer,

A non-enzymatic hydrolysis product of LTA4 with reduced activity compared to LTB4 also produced by oxidative decomposition of CysLTs such as LTC4 in the presence of myeloperoxidase and hypochlorous acid.

A non-enzymatic hydrolysis product of LTA4 with reduced activity compared to LTB4 also produced by oxidative decomposition of CysLTs such as LTC4 in the presence of myeloperoxidase and hypochlorous acid.

A non-enzymatic hydrolysis product of LTA4 with reduced activity compared to LTB4 also produced by oxidative decomposition of CysLTs such as LTC4 in the presence of myeloperoxidase and hypochlorous acid.

A non-enzymatic hydrolysis product of LTA4 with significantly reduced activity compared to LTB4.

A non-enzymatic hydrolysis product of LTA4 with significantly reduced activity compared to LTB4.

A non-enzymatic hydrolysis product of LTA4 with significantly reduced activity compared to LTB4.

A primary metabolite of the anti-cancer compound paclitaxel, produced by the action of the CYP450 isoform CYP2C8.

A primary metabolite of the anti-cancer compound paclitaxel, produced by the action of the CYP450 isoform CYP2C8.

A primary metabolite of the anti-cancer compound paclitaxel, produced by the action of the CYP450 isoform CYP2C8.