Biologically Active Small Molecules

8(S)-HEPE is a monohydroxy fatty acid produced by lipoxygenase oxidation of EPA. It acts to promote hatching of barnacle eggs at 10 nM, although it is not clearly identified as the natural egg hatching factor.

A major LO product in PMA-treated murine epidermis.

A major LO product in PMA-treated murine epidermis.

A major LO product in PMA-treated murine epidermis.

8(S)-HETrE is a monohydroxy PUFA produced by rabbit neutrophil lipoxygenase when DGLA is used as a substrate. Although the biological activities of 8(S)-HETrE have not been well characterized, it is expected to behave similarly to 8(S)-HETE.

8(S)-HETrE is a monohydroxy PUFA produced by rabbit neutrophil lipoxygenase when DGLA is used as a substrate. Although the biological activities of 8(S)-HETrE have not been well characterized, it is expected to behave similarly to 8(S)-HETE.

8(S)-HETrE is a monohydroxy PUFA produced by rabbit neutrophil lipoxygenase when DGLA is used as a substrate. Although the biological activities of 8(S)-HETrE have not been well characterized, it is expected to behave similarly to 8(S)-HETE.

8(S)-HETrE is a monohydroxy PUFA produced by rabbit neutrophil lipoxygenase when DGLA is used as a substrate. Although the biological activities of 8(S)-HETrE have not been well characterized, it is expected to behave similarly to 8(S)-HETE.

8(Z),14(Z)-Eicosadienoic acid is an &omega-8 C20:2 fatty acid. The presence of 8(Z),14(Z)-icosadienoic acid has been detected in human milk at a level of 0.

8(Z),14(Z)-Eicosadienoic acid is an &omega-8 C20:2 fatty acid. The presence of 8(Z),14(Z)-icosadienoic acid has been detected in human milk at a level of 0.

8(Z),14(Z)-Eicosadienoic acid is an &omega-8 C20:2 fatty acid. The presence of 8(Z),14(Z)-icosadienoic acid has been detected in human milk at a level of 0.

8,11,14-Eicosatriynoic acid is an inhibitor of prostaglandin and leukotriene biosynthesis as well as arachidonic acid induced platelet aggregation. It inhibits cyclooxygenase (IC50 = 14 &microM), human 12-lipoxygenase (IC50 = 0.