Biologically Active Small Molecules

A brominated derivative of guanosine that has been used to reduce the conformational heterogeneity of RNA to potentially enhance its function reported to activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.

8-Bromoisoquinoline is a synthetic intermediate useful for pharmaceutical synthesis.

8-Bromoisoquinoline is a synthetic intermediate useful for pharmaceutical synthesis.

8-Bromoisoquinoline is a synthetic intermediate useful for pharmaceutical synthesis.

A lipophilic activator of PKA and PKG (Ka = 0.05 and 0.11 &muM, respectively) inhibits PDE VA, PDE III, and PDE IV with IC50 values of 0.9, 24, and 25 &muM, respectively.

A lipophilic activator of PKA and PKG (Ka = 0.05 and 0.11 &muM, respectively) inhibits PDE VA, PDE III, and PDE IV with IC50 values of 0.9, 24, and 25 &muM, respectively.

A lipophilic activator of PKA and PKG (Ka = 0.05 and 0.11 &muM, respectively) inhibits PDE VA, PDE III, and PDE IV with IC50 values of 0.9, 24, and 25 &muM, respectively.

A fluorescently-labeled cyclic nucleotide to study cyclic nucleotide-gated A2 channel activation opens the channel in a rapid and reversible manner with efficiency equal to cGMP.

A fluorescently-labeled cyclic nucleotide to study cyclic nucleotide-gated A2 channel activation opens the channel in a rapid and reversible manner with efficiency equal to cGMP.

8-hydroxy Guanine is produced by oxidative damage of DNA or RNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a measure of oxidative stress in biological systems.

8-hydroxy Guanine is produced by oxidative damage of DNA or RNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a measure of oxidative stress in biological systems.

8-hydroxy Guanine is produced by oxidative damage of DNA or RNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a measure of oxidative stress in biological systems.