Biologically Active Small Molecules

A topoisomerase I inhibitor that is cytotoxic to HT-29 cells (IC₅₀ = 19 nM), induces DNA damage in whole cells (at 85 nM), and demonstrates significant anti-tumor activity.

A topoisomerase I inhibitor that is cytotoxic to HT-29 cells (IC₅₀ = 19 nM), induces DNA damage in whole cells (at 85 nM), and demonstrates significant anti-tumor activity.

Potently activates all isoforms of RAR (Ki = 0.5-27 nM) as well as RXR isoforms (Ki = 3.8-12 nM).

Potently activates all isoforms of RAR (Ki = 0.5-27 nM) as well as RXR isoforms (Ki = 3.8-12 nM).

Potently activates all isoforms of RAR (Ki = 0.5-27 nM) as well as RXR isoforms (Ki = 3.8-12 nM).

Potently activates all isoforms of RAR (Ki = 0.5-27 nM) as well as RXR isoforms (Ki = 3.8-12 nM).

9-deoxy-9-methylene PGE2 is a stable, isosteric analog of PGE2. 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects.

9-deoxy-9-methylene PGE2 is a stable, isosteric analog of PGE2. 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects.

9-deoxy-9-methylene PGE2 is a stable, isosteric analog of PGE2. 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects.

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 (PGE2 Item No. 14010) with an extended half-life in vivo.

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 (PGE2 Item No. 14010) with an extended half-life in vivo.

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 (PGE2 Item No. 14010) with an extended half-life in vivo.