Biologically Active Small Molecules

A divalent cation ionophore, commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways also used to produce apoptosis through calcium overload, as occurs during hypoxic or

A divalent cation ionophore, commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways also used to produce apoptosis through calcium overload, as occurs during hypoxic or

A divalent cation ionophore, commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways also used to produce apoptosis through calcium overload, as occurs during hypoxic or

A potent, peptide-competitive inhibitor of the lysine methyltransferase G9a (IC₅₀ = 3.3 nM) significantly reduces the cellular levels of dimethylation on histone 3 at lysine 9 (H3K9Me2) in PC3 cells also blocks the interaction of

A potent, peptide-competitive inhibitor of the lysine methyltransferase G9a (IC₅₀ = 3.3 nM) significantly reduces the cellular levels of dimethylation on histone 3 at lysine 9 (H3K9Me2) in PC3 cells also blocks the interaction of

A selective inhibitor of Src family kinases, with IC₅₀ values for Src, Lck, Lyn, and Hck of 9, 3, 3, and 0.43 nM, respectively induces growth arrest and apoptosis in chronic myelogenous leukemia cell lines prevents differentiation while

A selective inhibitor of Src family kinases, with IC₅₀ values for Src, Lck, Lyn, and Hck of 9, 3, 3, and 0.43 nM, respectively induces growth arrest and apoptosis in chronic myelogenous leukemia cell lines prevents differentiation while

A selective inhibitor of Src family kinases, with IC₅₀ values for Src, Lck, Lyn, and Hck of 9, 3, 3, and 0.43 nM, respectively induces growth arrest and apoptosis in chronic myelogenous leukemia cell lines prevents differentiation while

A selective inhibitor of Src family kinases, with IC₅₀ values for Src, Lck, Lyn, and Hck of 9, 3, 3, and 0.43 nM, respectively induces growth arrest and apoptosis in chronic myelogenous leukemia cell lines prevents differentiation while

A competitive antagonist of the nucleotide receptor P2X7 (pIC₅₀ = 6.9) inhibits both calcium flux and IL-1&beta release mediated by P2X7 while not affecting the activity of other P2X receptors used to evaluate the role of P2X7 in

A competitive antagonist of the nucleotide receptor P2X7 (pIC₅₀ = 6.9) inhibits both calcium flux and IL-1&beta release mediated by P2X7 while not affecting the activity of other P2X receptors used to evaluate the role of P2X7 in

A pan Akt inhibitor (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation slows the progression of Akt-dependent tumors in vivo concomitantly increases Akt Thr308 and Ser473 phosphorylation