Biologically Active Small Molecules

A pan Akt inhibitor (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation slows the progression of Akt-dependent tumors in vivo concomitantly increases Akt Thr308 and Ser473 phosphorylation

A pan Akt inhibitor (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation slows the progression of Akt-dependent tumors in vivo concomitantly increases Akt Thr308 and Ser473 phosphorylation

A natural (ADEP) antibiotic that constitutively activates the bacterial protease ClpP, resulting in uncontrolled proteolysis, inhibition of bacterial cell division, and, ultimately, cell death preferentially targets Gram-positive bacteria.

A natural (ADEP) antibiotic that constitutively activates the bacterial protease ClpP, resulting in uncontrolled proteolysis, inhibition of bacterial cell division, and, ultimately, cell death preferentially targets Gram-positive bacteria.

A natural acyldepsipeptide that is effective against Gram-positive bacteria, including penicillin-resistant S. aureus is also effective against many strains of anaerobic bacteria.

A natural acyldepsipeptide that is effective against Gram-positive bacteria, including penicillin-resistant S. aureus is also effective against many strains of anaerobic bacteria.

A selective &alpha1A-adrenergic receptor agonist that is at least 35-fold more potent at &alpha1A receptor sites than at &alpha1B or &alpha1D increases the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro with

A selective &alpha1A-adrenergic receptor agonist that is at least 35-fold more potent at &alpha1A receptor sites than at &alpha1B or &alpha1D increases the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro with

A selective &alpha1A-adrenergic receptor agonist that is at least 35-fold more potent at &alpha1A receptor sites than at &alpha1B or &alpha1D increases the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro with

An orally available, reversible inhibitor of Akt (Ki = 11 nM for Akt1) also inhibits PKA and Cdk2 with IC₅₀ values of 16 and 46 nM, respectively reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor

An orally available, reversible inhibitor of Akt (Ki = 11 nM for Akt1) also inhibits PKA and Cdk2 with IC₅₀ values of 16 and 46 nM, respectively reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor

An orally available, reversible inhibitor of Akt (Ki = 11 nM for Akt1) also inhibits PKA and Cdk2 with IC₅₀ values of 16 and 46 nM, respectively reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor