Biologically Active Small Molecules

A potent and selective competitive antagonist of the P2X₇ receptor.

A potent inhibitor of DGAT-1 (IC50s = 7 and 24 nM, for human and mouse, respectively) confers significant weight loss within seven days and significantly reduces plasma and liver triglycerides when administered at 3 mg/kg to DIO mice.

A potent inhibitor of DGAT-1 (IC50s = 7 and 24 nM, for human and mouse, respectively) confers significant weight loss within seven days and significantly reduces plasma and liver triglycerides when administered at 3 mg/kg to DIO mice.

A potent inhibitor of DGAT-1 (IC50s = 7 and 24 nM, for human and mouse, respectively) confers significant weight loss within seven days and significantly reduces plasma and liver triglycerides when administered at 3 mg/kg to DIO mice.

A potent inhibitor of DGAT-1 (IC50s = 7 and 24 nM, for human and mouse, respectively) confers significant weight loss within seven days and significantly reduces plasma and liver triglycerides when administered at 3 mg/kg to DIO mice.

A potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC₅₀ values of 67 and 289 nM for the human and rat isoforms, respectively attenuates cold allodynia following nerve injury and suppresses neuronal activity in

A potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC₅₀ values of 67 and 289 nM for the human and rat isoforms, respectively attenuates cold allodynia following nerve injury and suppresses neuronal activity in

A potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC₅₀ values of 67 and 289 nM for the human and rat isoforms, respectively attenuates cold allodynia following nerve injury and suppresses neuronal activity in

A potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC₅₀ values of 67 and 289 nM for the human and rat isoforms, respectively attenuates cold allodynia following nerve injury and suppresses neuronal activity in

Amitraz is an agonist at a-adrenergic receptors that displays insecticide activity. Amitraz also inhibits monoamine oxidase (MAO) and synthesis of prostaglandins.

Amitraz is an agonist at a-adrenergic receptors that displays insecticide activity. Amitraz also inhibits monoamine oxidase (MAO) and synthesis of prostaglandins.

Amitraz is an agonist at a-adrenergic receptors that displays insecticide activity. Amitraz also inhibits monoamine oxidase (MAO) and synthesis of prostaglandins.