Biologically Active Small Molecules

A reactive metabolite of tamoxifen that is formed by the action of CYP3A4 in human liver can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety.

An &alpha-hydroxy acid, overproduced in 2-hydroxyglutaric aciduria mutations in IDH1 and IDH2 cause these enzymes to convert isocitrate to 2-hydroxyglutarate competitively inhibits &alpha-ketoglutarate-dependent dioxygenases, including lysine

An &alpha-hydroxy acid, overproduced in 2-hydroxyglutaric aciduria mutations in IDH1 and IDH2 cause these enzymes to convert isocitrate to 2-hydroxyglutarate competitively inhibits &alpha-ketoglutarate-dependent dioxygenases, including lysine

An &alpha-hydroxy acid, overproduced in 2-hydroxyglutaric aciduria mutations in IDH1 and IDH2 cause these enzymes to convert isocitrate to 2-hydroxyglutarate competitively inhibits &alpha-ketoglutarate-dependent dioxygenases, including lysine

ALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.

ALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.

ALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.

An internal standard for the quantification of ALA by GC- or LC-MS.

An internal standard for the quantification of ALA by GC- or LC-MS.

An internal standard for the quantification of ALA by GC- or LC-MS.

An internal standard for the quantification of ALA by GC- or LC-MS.

An internal standard for the quantification of ALA by GC- or LC-MS.