Biologically Active Small Molecules

An acetylated synthetic peptide from human calpastatin that strongly inhibits both calpains I and II but not papain or trypsin.

Mast cell stabilizer used to treat seasonal allergic rhinitis.

Mast cell stabilizer used to treat seasonal allergic rhinitis.

Mast cell stabilizer used to treat seasonal allergic rhinitis.

A fluorogenic substrate for activated caspase-3 (Km = 9.7 &microM), as well as related caspases caspase activity can be quantified by fluorescent detection of free AFC, which is excited at 400 nm and emits at 505 nm.

A fluorogenic substrate for activated caspase-3 (Km = 9.7 &microM), as well as related caspases caspase activity can be quantified by fluorescent detection of free AFC, which is excited at 400 nm and emits at 505 nm.

A fluorogenic substrate for activated caspase-3 (Km = 9.7 &microM), as well as related caspases caspase activity can be quantified by fluorescent detection of free AFC, which is excited at 400 nm and emits at 505 nm.

A fluorogenic substrate that can be cleaved specifically by caspase-3.

A fluorogenic substrate that can be cleaved specifically by caspase-3.

A fluorogenic substrate that can be cleaved specifically by caspase-3.

A potent, reversible inhibitor of caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively) also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).

A potent, reversible inhibitor of caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively) also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).