Biologically Active Small Molecules

A potent, reversible inhibitor of caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively) also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).

A potent, reversible inhibitor of caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively) also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).

A cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10.

A cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10.

A para-nitro aniline chromophore cleaved by caspases (Km = 18, 11, 32, 180, and 12 &microM for caspases-1, -3, -4, -6, and -7, respectively) not cleaved by caspase-2 monitored colorimetrically at 405 nm.

A para-nitro aniline chromophore cleaved by caspases (Km = 18, 11, 32, 180, and 12 &microM for caspases-1, -3, -4, -6, and -7, respectively) not cleaved by caspase-2 monitored colorimetrically at 405 nm.

A para-nitro aniline chromophore cleaved by caspases (Km = 18, 11, 32, 180, and 12 &microM for caspases-1, -3, -4, -6, and -7, respectively) not cleaved by caspase-2 monitored colorimetrically at 405 nm.

Substrate used to measure caspase activity. Grade: &ge95%

A fluorogenic substrate that can be cleaved specifically by caspase-8, caspase-3 processing enzyme, caspase-10, and granzyme B.

A fluorogenic substrate that can be cleaved specifically by caspase-8, caspase-3 processing enzyme, caspase-10, and granzyme B.

A fluorogenic substrate that can be cleaved specifically by caspase-8, caspase-3 processing enzyme, caspase-10, and granzyme B.

A fluorogenic substrate that can be cleaved by caspase-4, -5, and -9.