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17713-5A selective FFAR4 antagonist (pIC<sub>50</sub>s = 7.1 versus < 4.6 for human FFAR4 and FFAR1 receptors, respectively) that inhibits intracellular calcium accumulation induced by either linoleic acid or an FFAR4 agonist.
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10010241-100A selective activator of AMPK inhibits synthesis of fatty acids and sterols in hepatocytes and insulin-stimulated glucose uptake in adipocytes.
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10010241-250A selective activator of AMPK inhibits synthesis of fatty acids and sterols in hepatocytes and insulin-stimulated glucose uptake in adipocytes.
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10010241-50A selective activator of AMPK inhibits synthesis of fatty acids and sterols in hepatocytes and insulin-stimulated glucose uptake in adipocytes.
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10010241-500A selective activator of AMPK inhibits synthesis of fatty acids and sterols in hepatocytes and insulin-stimulated glucose uptake in adipocytes.
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14004-10A cell- and brain-permeable inhibitor of SIRT2 (IC<sub>50</sub> = 15.5 &muM) dimishes neuronal cell death induced by mutant huntingtin fragment in culture down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol
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14004-25A cell- and brain-permeable inhibitor of SIRT2 (IC<sub>50</sub> = 15.5 &muM) dimishes neuronal cell death induced by mutant huntingtin fragment in culture down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol
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14004-5A cell- and brain-permeable inhibitor of SIRT2 (IC<sub>50</sub> = 15.5 &muM) dimishes neuronal cell death induced by mutant huntingtin fragment in culture down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol
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14004-50A cell- and brain-permeable inhibitor of SIRT2 (IC<sub>50</sub> = 15.5 &muM) dimishes neuronal cell death induced by mutant huntingtin fragment in culture down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol
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14870-1A potent, allosteric inhibitor of Akt1 and Akt2 (IC<sub>50</sub> = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC<sub>50</sub> = 2.2 µM) cell permeable, blocking insulin regulation of FOXO1 activity at 1 µM
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14870-10A potent, allosteric inhibitor of Akt1 and Akt2 (IC<sub>50</sub> = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC<sub>50</sub> = 2.2 µM) cell permeable, blocking insulin regulation of FOXO1 activity at 1 µM
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14870-5A potent, allosteric inhibitor of Akt1 and Akt2 (IC<sub>50</sub> = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC<sub>50</sub> = 2.2 µM) cell permeable, blocking insulin regulation of FOXO1 activity at 1 µM