Biologically Active Small Molecules

An isomer of hypoxanthine that inhibits xanthine oxidoreductase (IC50 values between 0.2 and 50 &muM) lowers serum and urinary uric acid levels in vivo and is used to treat gout and hyperuricemia.

A toxin that selectively eliminates pancreatic &beta-cells in mice, rats, and certain other animals, and is used to model type 1 diabetes in humans.

A toxin that selectively eliminates pancreatic &beta-cells in mice, rats, and certain other animals, and is used to model type 1 diabetes in humans.

Alloxan is an oxygenated pyrimidine and toxic analog of glucose. Alloxan destroys ß cells and is used in research models to induce diabetes. This compound does not affect human cells.

Alloxan is an oxygenated pyrimidine and toxic analog of glucose. Alloxan destroys ß cells and is used in research models to induce diabetes. This compound does not affect human cells.

Alloxan is an oxygenated pyrimidine and toxic analog of glucose. Alloxan destroys ß cells and is used in research models to induce diabetes. This compound does not affect human cells.

A dual orexin 1 and 2 receptor antagonist (Kds = 1.3 and 0.17 nM, respectively) 100 mg/kg promotes nonrapid eye movement sleep and exacerbates cataplexy in a mouse model of narcolepsy.

A dual orexin 1 and 2 receptor antagonist (Kds = 1.3 and 0.17 nM, respectively) 100 mg/kg promotes nonrapid eye movement sleep and exacerbates cataplexy in a mouse model of narcolepsy.

A dual orexin 1 and 2 receptor antagonist (Kds = 1.3 and 0.17 nM, respectively) 100 mg/kg promotes nonrapid eye movement sleep and exacerbates cataplexy in a mouse model of narcolepsy.

Functions as a potent laxative by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle also demonstrates anti-tumor activity (ED50s = 1-13 &microM), inducing apoptosis

Functions as a potent laxative by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle also demonstrates anti-tumor activity (ED50s = 1-13 &microM), inducing apoptosis

Functions as a potent laxative by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle also demonstrates anti-tumor activity (ED50s = 1-13 &microM), inducing apoptosis