Biologically Active Small Molecules

A first generation tricyclic antidepressant blocks the serotonin and norepinephrine transporters (Kds = 4.3 and 35 nM, respectively) inhibits 5-HT2A receptor (Ki =20 nM) antagonizes histamine H1, muscarinic acetylcholine, and &alpha1-adrenergic

An anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers, commonly used as a 5% topical oral paste associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at

An anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers, commonly used as a 5% topical oral paste associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at

An anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers, commonly used as a 5% topical oral paste associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at

A dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle inhibits calcium-induced contractions in depolarized rat aorta (IC₅₀ = 1.9 nM), displaying a slow rate of

A dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle inhibits calcium-induced contractions in depolarized rat aorta (IC₅₀ = 1.9 nM), displaying a slow rate of

A dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle inhibits calcium-induced contractions in depolarized rat aorta (IC₅₀ = 1.9 nM), displaying a slow rate of

An aminoquinoline antimalarial compound metabolized primarily by CYP2C8 to N-desethylaminodiaquine, which is highly active against P. falciparum and can synergize with amodiaquine commonly used in combination therapy.

An aminoquinoline antimalarial compound metabolized primarily by CYP2C8 to N-desethylaminodiaquine, which is highly active against P. falciparum and can synergize with amodiaquine commonly used in combination therapy.

An aminoquinoline antimalarial compound metabolized primarily by CYP2C8 to N-desethylaminodiaquine, which is highly active against P. falciparum and can synergize with amodiaquine commonly used in combination therapy.

An aminoquinoline antimalarial compound metabolized primarily by CYP2C8 to N-desethylaminodiaquine, which is highly active against P. falciparum and can synergize with amodiaquine commonly used in combination therapy.

A PPAR&gamma agonist (Ki = 19 nM EC₅₀ = 73 nM) that was first isolated from A. fruticosa 100 mg/kg/day improves insulin sensitivity, glucose tolerance, and plasma lipid concentrations after two weeks of treatment in insulin-resistant