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10626-10An agonist of GPR199 that is effective both in isolated cells and in vivo increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 &muM) and promotes glucose-stimulated insulin secretion in mice (100 mg/kg).
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10626-25An agonist of GPR199 that is effective both in isolated cells and in vivo increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 &muM) and promotes glucose-stimulated insulin secretion in mice (100 mg/kg).
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10626-5An agonist of GPR199 that is effective both in isolated cells and in vivo increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 &muM) and promotes glucose-stimulated insulin secretion in mice (100 mg/kg).
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14978-1Formal Name: N-[(1S)-2-hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea CAS Number: 928320-12-1 Molecular Formula: C<sub>20</sub>H<sub>19</sub>N<sub>3</sub>O<sub>2</sub>
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14978-10Formal Name: N-[(1S)-2-hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea CAS Number: 928320-12-1 Molecular Formula: C<sub>20</sub>H<sub>19</sub>N<sub>3</sub>O<sub>2</sub>
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14978-25Formal Name: N-[(1S)-2-hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea CAS Number: 928320-12-1 Molecular Formula: C<sub>20</sub>H<sub>19</sub>N<sub>3</sub>O<sub>2</sub>
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14978-5Formal Name: N-[(1S)-2-hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea CAS Number: 928320-12-1 Molecular Formula: C<sub>20</sub>H<sub>19</sub>N<sub>3</sub>O<sub>2</sub>
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17627-1A selective inhibitor of SHIP2 (IC<sub>50</sub>s = 0.62 and 0.34 µM for human and mouse, respectively Ki = 0.44 µM for hSHIP2) dose-dependently increases insulin-induced phosphorylation of Akt and activates glucose metabolism.
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17627-10A selective inhibitor of SHIP2 (IC<sub>50</sub>s = 0.62 and 0.34 µM for human and mouse, respectively Ki = 0.44 µM for hSHIP2) dose-dependently increases insulin-induced phosphorylation of Akt and activates glucose metabolism.
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17627-5A selective inhibitor of SHIP2 (IC<sub>50</sub>s = 0.62 and 0.34 µM for human and mouse, respectively Ki = 0.44 µM for hSHIP2) dose-dependently increases insulin-induced phosphorylation of Akt and activates glucose metabolism.
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17627-50A selective inhibitor of SHIP2 (IC<sub>50</sub>s = 0.62 and 0.34 µM for human and mouse, respectively Ki = 0.44 µM for hSHIP2) dose-dependently increases insulin-induced phosphorylation of Akt and activates glucose metabolism.
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10009052-1A potent inhibitor of PI3K with selectivity for the g isoform inhibits human recombinant PI3Kg, a, d, with IC50 values of 30, 940, 20,000, and 20,000 nM, respectively.