Biologically Active Small Molecules

Inhibitor of NF-&kappaB activation that blocks the phosphorylation of IKK and I&kappaB (IC50 ~ 40 &muM) dose dependently inhibits the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells.

Inhibitor of NF-&kappaB activation that blocks the phosphorylation of IKK and I&kappaB (IC50 ~ 40 &muM) dose dependently inhibits the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells.

A minor component of avermectin broth, used broadly against nematodes, ticks, flies, and ants.

A minor component of avermectin broth, used broadly against nematodes, ticks, flies, and ants.

A selective, irreversible inhibitor of BTK (IC₅₀ = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481 inhibits osteoclast function and reduces osteoclast-stimulated proliferation of

A selective, irreversible inhibitor of BTK (IC₅₀ = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481 inhibits osteoclast function and reduces osteoclast-stimulated proliferation of

A selective, irreversible inhibitor of BTK (IC₅₀ = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481 inhibits osteoclast function and reduces osteoclast-stimulated proliferation of

A selective, irreversible inhibitor of BTK (IC₅₀ = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481 inhibits osteoclast function and reduces osteoclast-stimulated proliferation of

A partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.

A partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.

A partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.

A partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.