Biologically Active Small Molecules

A potent, selective inhibitor of ATR (IC₅₀ = 5 nM) inhibits the growth of LoVo colorectal adenocarcinoma cells in vitro and significantly reduces the growth of LoVo xenografts in mice.

A potent, selective inhibitor of ATR (IC₅₀ = 5 nM) inhibits the growth of LoVo colorectal adenocarcinoma cells in vitro and significantly reduces the growth of LoVo xenografts in mice.

AZ 5104 is an active, demethylated metabolite of AZD 9291 (Item No. 16237), an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC₅₀s = 15-17 nM) that spares the wild-type form of the receptor (IC₅₀ =

AZ 5104 is an active, demethylated metabolite of AZD 9291 (Item No. 16237), an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC₅₀s = 15-17 nM) that spares the wild-type form of the receptor (IC₅₀ =

AZ 5104 is an active, demethylated metabolite of AZD 9291 (Item No. 16237), an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC₅₀s = 15-17 nM) that spares the wild-type form of the receptor (IC₅₀ =

AZ 5104 is an active, demethylated metabolite of AZD 9291 (Item No. 16237), an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC₅₀s = 15-17 nM) that spares the wild-type form of the receptor (IC₅₀ =

A TNKS1/2 inhibitor.

A TNKS1/2 inhibitor.

A TNKS1/2 inhibitor.

A TNKS1/2 inhibitor.

A quinazilinone that inhibits several Raf kinases, including B-Raf, B-RafV600E, and c-Raf-1 (IC₅₀s = 105, 34, and 29 nM in vitro) inhibits anchorage-dependent and -independent growth, induces cell cycle arrest, and causes apoptosis in

A quinazilinone that inhibits several Raf kinases, including B-Raf, B-RafV600E, and c-Raf-1 (IC₅₀s = 105, 34, and 29 nM in vitro) inhibits anchorage-dependent and -independent growth, induces cell cycle arrest, and causes apoptosis in