Biologically Active Small Molecules

A quinazilinone that inhibits several Raf kinases, including B-Raf, B-RafV600E, and c-Raf-1 (IC₅₀s = 105, 34, and 29 nM in vitro) inhibits anchorage-dependent and -independent growth, induces cell cycle arrest, and causes apoptosis in

A quinazilinone that inhibits several Raf kinases, including B-Raf, B-RafV600E, and c-Raf-1 (IC₅₀s = 105, 34, and 29 nM in vitro) inhibits anchorage-dependent and -independent growth, induces cell cycle arrest, and causes apoptosis in

AZ 7371 is a non-covalent inhibitor of decaprenylphosphoryl-&beta-D-ribose 2&rsquo-epimerase (DprE1) with an IC₅₀ value of 10 nM. It also inhibits PDE6 with an IC₅₀ value of 4 &microM.

AZ 7371 is a non-covalent inhibitor of decaprenylphosphoryl-&beta-D-ribose 2&rsquo-epimerase (DprE1) with an IC₅₀ value of 10 nM. It also inhibits PDE6 with an IC₅₀ value of 4 &microM.

AZ 7371 is a non-covalent inhibitor of decaprenylphosphoryl-&beta-D-ribose 2&rsquo-epimerase (DprE1) with an IC₅₀ value of 10 nM. It also inhibits PDE6 with an IC₅₀ value of 4 &microM.

AZ 7371 is a non-covalent inhibitor of decaprenylphosphoryl-&beta-D-ribose 2&rsquo-epimerase (DprE1) with an IC₅₀ value of 10 nM. It also inhibits PDE6 with an IC₅₀ value of 4 &microM.

A potent JAK2 inhibitor (Ki = 0.45 nM in vitro) that decrease STAT3/5 phosphorylation and inhibits cell proliferation (GI50 = 33 nM) in a JAK2 V617F mutated cell line induces apoptosis in human T cell lymophotropic virus type 1-infected

A potent JAK2 inhibitor (Ki = 0.45 nM in vitro) that decrease STAT3/5 phosphorylation and inhibits cell proliferation (GI50 = 33 nM) in a JAK2 V617F mutated cell line induces apoptosis in human T cell lymophotropic virus type 1-infected

A potent JAK2 inhibitor (Ki = 0.45 nM in vitro) that decrease STAT3/5 phosphorylation and inhibits cell proliferation (GI50 = 33 nM) in a JAK2 V617F mutated cell line induces apoptosis in human T cell lymophotropic virus type 1-infected

A DYRK1B inhibitor (IC₅₀ = 17 nM) that demonstrates 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle

A DYRK1B inhibitor (IC₅₀ = 17 nM) that demonstrates 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle

A DYRK1B inhibitor (IC₅₀ = 17 nM) that demonstrates 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle