Biologically Active Small Molecules

A PARP inhibitor (IC₅₀ = 5 nM) with low affinity for the P-glycoprotein drug efflux transporter induces a loss of p53 binding protein 1 expression in mice with KB1P tumors at 100 mg/kg.

A PARP inhibitor (IC₅₀ = 5 nM) with low affinity for the P-glycoprotein drug efflux transporter induces a loss of p53 binding protein 1 expression in mice with KB1P tumors at 100 mg/kg.

A GSK3&beta inhibitor (Ki = 4.9 nM) that crosses the blood brain barrier and inhibits tau phosphorylation (IC₅₀ = 76 nM in vitro) stabilizes &beta-catenin and increases bone mass (via Wnt activation) in rats after a two-week treatment

A GSK3&beta inhibitor (Ki = 4.9 nM) that crosses the blood brain barrier and inhibits tau phosphorylation (IC₅₀ = 76 nM in vitro) stabilizes &beta-catenin and increases bone mass (via Wnt activation) in rats after a two-week treatment

A GSK3&beta inhibitor (Ki = 4.9 nM) that crosses the blood brain barrier and inhibits tau phosphorylation (IC₅₀ = 76 nM in vitro) stabilizes &beta-catenin and increases bone mass (via Wnt activation) in rats after a two-week treatment

CAS Number: 883986-34-3 Molecular Formula: C₂₄H₂₅N₅O₄ Formula Weight: 447.5

CAS Number: 883986-34-3 Molecular Formula: C₂₄H₂₅N₅O₄ Formula Weight: 447.5

CAS Number: 883986-34-3 Molecular Formula: C₂₄H₂₅N₅O₄ Formula Weight: 447.5

CAS Number: 883986-34-3 Molecular Formula: C₂₄H₂₅N₅O₄ Formula Weight: 447.5

A selective inhibitor of MCT1 (Ki = 1.6 nM), killing tumor cells that are reliant on glycolysis by blocking lactate transport increases intratumor lactate levels and decreases tumor growth in mice bearing SCLC xenografts.

A selective inhibitor of MCT1 (Ki = 1.6 nM), killing tumor cells that are reliant on glycolysis by blocking lactate transport increases intratumor lactate levels and decreases tumor growth in mice bearing SCLC xenografts.

A selective inhibitor of MCT1 (Ki = 1.6 nM), killing tumor cells that are reliant on glycolysis by blocking lactate transport increases intratumor lactate levels and decreases tumor growth in mice bearing SCLC xenografts.