Biologically Active Small Molecules

Thiamine/vitamin B derivative and antioxidant. It displays several biological activities, including inhibiting pain neurotransmission, decreasing production of production of amyloid-&beta, and inhibiting LPS-induced release of leukotrienes,

An inhibitor of AADC, an enzyme that has dopamine decarboxylase activity, to block the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system.

An inhibitor of AADC, an enzyme that has dopamine decarboxylase activity, to block the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system.

An inhibitor of AADC, an enzyme that has dopamine decarboxylase activity, to block the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system.

An inhibitor of AADC, an enzyme that has dopamine decarboxylase activity, to block the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system.

An inhibitor of URAT1 (IC₅₀ = 0.3 &microM for hURAT1) that prevents renal urate resorption also potently inhibits CYP2C9 (Ki = 20 nM) and has been used to study adverse drug-drug interactions.

An inhibitor of URAT1 (IC₅₀ = 0.3 &microM for hURAT1) that prevents renal urate resorption also potently inhibits CYP2C9 (Ki = 20 nM) and has been used to study adverse drug-drug interactions.

An inhibitor of URAT1 (IC₅₀ = 0.3 &microM for hURAT1) that prevents renal urate resorption also potently inhibits CYP2C9 (Ki = 20 nM) and has been used to study adverse drug-drug interactions.

Benzimidazole is an organic compound that displays some anticancer benefit. Complexes of Cu(II) and benzimidazole bind to the minor groove of DNA, cleave supercoiled DNA, and inhibit topoisomerase I, inhibiting proliferation across several cancer

Benzimidazole is an organic compound that displays some anticancer benefit. Complexes of Cu(II) and benzimidazole bind to the minor groove of DNA, cleave supercoiled DNA, and inhibit topoisomerase I, inhibiting proliferation across several cancer

Benzimidazole is an organic compound that displays some anticancer benefit. Complexes of Cu(II) and benzimidazole bind to the minor groove of DNA, cleave supercoiled DNA, and inhibit topoisomerase I, inhibiting proliferation across several cancer

A centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki = 0.59 nM in rat) that also inhibits dopamine uptake through the dopamine transporter (Ki = 160 nM) used in the management of Parkinson&rsquos disease symptoms to address