Biologically Active Small Molecules

A PARP inhibitor and insulin sensitizer blocks self-ADP-ribosylation of nuclear PARP (Ki = 57 &microM) and mono-ADP-ribosylation of GRP78 acts as a co-inducer of Hsp72, augmenting expression induced by Hsf1 in adipocytes and skeletal muscles and

A cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki

A cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki

A cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki

A cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki

4-Tert-butyl-5-methoxy-catechol exhibits anticancer activity, inhibiting proliferation of leukemia cells.

3-Tert-butyl-5-methoxy-1,2-quinone exhibits anticancer activity, inhibiting proliferation of leukemia cells.

4-Tert-butyl-5-methoxy-1,2-quinone exhibits anticancer activity, inhibiting proliferation of leukemia cells.

3-Tert-butyl-5-methoxy-1,2-quinone exhibits anticancer activity, inhibiting proliferation of leukemia cells.

4-Tert-butyl-5-methoxy-catechol exhibits anticancer activity, inhibiting proliferation of leukemia cells.

4-Tert-butyl-5-methoxy-1,2-quinone exhibits anticancer activity, inhibiting proliferation of leukemia cells.

4-Tert-butyl-5-methoxy-catechol exhibits anticancer activity, inhibiting proliferation of leukemia cells.