Biologically Active Small Molecules

A dihydropteridinone that inhibits Plk1, Plk2, and Plk3 (IC₅₀s = 0.87, 5, and 56 nM, respectively), inducing mitotic arrest and apoptosis inhibits proliferation of multiple cancer cell lines (EC₅₀s = 11-37 nM) and prevents the

A dihydropteridinone that inhibits Plk1, Plk2, and Plk3 (IC₅₀s = 0.87, 5, and 56 nM, respectively), inducing mitotic arrest and apoptosis inhibits proliferation of multiple cancer cell lines (EC₅₀s = 11-37 nM) and prevents the

A dihydropteridinone that inhibits Plk1, Plk2, and Plk3 (IC₅₀s = 0.87, 5, and 56 nM, respectively), inducing mitotic arrest and apoptosis inhibits proliferation of multiple cancer cell lines (EC₅₀s = 11-37 nM) and prevents the

An inhibitor of tBid (Kd = 20 &microM), blocking the release of both cytochrome c and Smac from mitochondria prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation inhibits the nuclear translocation of AIF, preventing

An inhibitor of tBid (Kd = 20 &microM), blocking the release of both cytochrome c and Smac from mitochondria prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation inhibits the nuclear translocation of AIF, preventing

An inhibitor of tBid (Kd = 20 &microM), blocking the release of both cytochrome c and Smac from mitochondria prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation inhibits the nuclear translocation of AIF, preventing

A potent BRD9 bromodomain inhibitor.

A potent BRD9 bromodomain inhibitor.

A potent BRD9 bromodomain inhibitor.

A potent BRD9 bromodomain inhibitor.

A selective dual MEK/Aurora kinase inhibitor (IC₅₀s = 3, 25, 15, 25, and 4 nM for X. laevis Aurora B, human Aurora A and Aurora C, and human MEK1 and MEK2, respectively) inhibits the growth and survival of both treatment-na&iumlve and

A selective dual MEK/Aurora kinase inhibitor (IC₅₀s = 3, 25, 15, 25, and 4 nM for X. laevis Aurora B, human Aurora A and Aurora C, and human MEK1 and MEK2, respectively) inhibits the growth and survival of both treatment-na&iumlve and