Biologically Active Small Molecules

A selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM IC₅₀s = 75 nM and 3.

A selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM IC₅₀s = 75 nM and 3.

A selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM IC₅₀s = 75 nM and 3.

A cell permeable, ATP-competitive inhibitor of the four vertebrate isoforms of RSK, RSK1-4 (IC₅₀s = 31, 24, 18, and 15 nM, respectively) also significantly inhibits PLK1, Aurora B, MELK, and MST2 at 100 nM.

A cell permeable, ATP-competitive inhibitor of the four vertebrate isoforms of RSK, RSK1-4 (IC₅₀s = 31, 24, 18, and 15 nM, respectively) also significantly inhibits PLK1, Aurora B, MELK, and MST2 at 100 nM.

A cell permeable, ATP-competitive inhibitor of the four vertebrate isoforms of RSK, RSK1-4 (IC₅₀s = 31, 24, 18, and 15 nM, respectively) also significantly inhibits PLK1, Aurora B, MELK, and MST2 at 100 nM.

A small molecule antagonist of HNF4&alpha that at 20 &muM reduces endogenous insulin gene expression by as much as 50-fold in T6PNE cells induces hepatic steatosis in vivo and is cyctotoxic to human hepatocellular carcinoma cell lines.

A small molecule antagonist of HNF4&alpha that at 20 &muM reduces endogenous insulin gene expression by as much as 50-fold in T6PNE cells induces hepatic steatosis in vivo and is cyctotoxic to human hepatocellular carcinoma cell lines.

A small molecule antagonist of HNF4&alpha that at 20 &muM reduces endogenous insulin gene expression by as much as 50-fold in T6PNE cells induces hepatic steatosis in vivo and is cyctotoxic to human hepatocellular carcinoma cell lines.

A natural non-selective phytotoxin that is converted in vivo to the active agent phosphinothricin, which inhibits glutamine synthetase (Ki = 6.1 &microM) used in the selection of transgenic plants that express the bar gene, usually under the

A natural non-selective phytotoxin that is converted in vivo to the active agent phosphinothricin, which inhibits glutamine synthetase (Ki = 6.1 &microM) used in the selection of transgenic plants that express the bar gene, usually under the

A natural non-selective phytotoxin that is converted in vivo to the active agent phosphinothricin, which inhibits glutamine synthetase (Ki = 6.1 &microM) used in the selection of transgenic plants that express the bar gene, usually under the