Biologically Active Small Molecules

A selective and potent inhibitor of 2,3-oxidosqualene cyclase (OSC) in vivo with an ED50 value of 0.2-0.

A selective and potent inhibitor of 2,3-oxidosqualene cyclase (OSC) in vivo with an ED50 value of 0.2-0.

A selective and potent inhibitor of 2,3-oxidosqualene cyclase (OSC) in vivo with an ED50 value of 0.2-0.

A selective and potent inhibitor of 2,3-oxidosqualene cyclase (OSC) in vivo with an ED50 value of 0.2-0.

A triple receptor tyrosine kinase inhibitor, blocking signaling through VEGFR (IC50 = 13-34 nM), PDGFR (IC50 = 59-65 nM), and FGFR (IC50 = 37-610 nM) inhibits angiogenesis has potential applications in various forms of cancer and pulmonary

A triple receptor tyrosine kinase inhibitor, blocking signaling through VEGFR (IC50 = 13-34 nM), PDGFR (IC50 = 59-65 nM), and FGFR (IC50 = 37-610 nM) inhibits angiogenesis has potential applications in various forms of cancer and pulmonary

A triple receptor tyrosine kinase inhibitor, blocking signaling through VEGFR (IC50 = 13-34 nM), PDGFR (IC50 = 59-65 nM), and FGFR (IC50 = 37-610 nM) inhibits angiogenesis has potential applications in various forms of cancer and pulmonary

A mixed-type non-competitive inhibitor of telomerase (IC₅₀ = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase induces senescence or apoptosis in cancer

A mixed-type non-competitive inhibitor of telomerase (IC₅₀ = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase induces senescence or apoptosis in cancer

A mixed-type non-competitive inhibitor of telomerase (IC₅₀ = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase induces senescence or apoptosis in cancer

A mixed-type non-competitive inhibitor of telomerase (IC₅₀ = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase induces senescence or apoptosis in cancer

Selective and irreversible dual inhibitor of EGFR and HER2 kinase activity (IC50s = 0.5 and 14 nM, respectively) suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines, and at 20 mg/kg, induces tumor