Biologically Active Small Molecules

Selective and irreversible dual inhibitor of EGFR and HER2 kinase activity (IC50s = 0.5 and 14 nM, respectively) suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines, and at 20 mg/kg, induces tumor

Selective and irreversible dual inhibitor of EGFR and HER2 kinase activity (IC50s = 0.5 and 14 nM, respectively) suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines, and at 20 mg/kg, induces tumor

Selective and irreversible dual inhibitor of EGFR and HER2 kinase activity (IC50s = 0.5 and 14 nM, respectively) suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines, and at 20 mg/kg, induces tumor

A non-steroidal antiandrogen that binds the androgen receptor (Ki = 12.5 &muM IC₅₀ = 1.2 &muM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones.

A non-steroidal antiandrogen that binds the androgen receptor (Ki = 12.5 &muM IC₅₀ = 1.2 &muM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones.

A non-steroidal antiandrogen that binds the androgen receptor (Ki = 12.5 &muM IC₅₀ = 1.2 &muM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones.

A non-steroidal antiandrogen that binds the androgen receptor (Ki = 12.5 &muM IC₅₀ = 1.2 &muM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones.

A competitive GABAA receptor antagonist that at 100 &muM blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons reversibly blocks GABAA receptors on horizontal cells in the mouse retina (IC50 =

A competitive GABAA receptor antagonist that at 100 &muM blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons reversibly blocks GABAA receptors on horizontal cells in the mouse retina (IC50 =

A competitive GABAA receptor antagonist that at 100 &muM blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons reversibly blocks GABAA receptors on horizontal cells in the mouse retina (IC50 =

Bicyclo Prostaglandin E1 (bicyclo PGE1) is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. Bicyclo PGE1 is a stable, base-catalyzed transformation product of the PGE1 metabolite

Bicyclo Prostaglandin E1 (bicyclo PGE1) is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. Bicyclo PGE1 is a stable, base-catalyzed transformation product of the PGE1 metabolite