Biologically Active Small Molecules

Bicyclo PGE2 is a stable, base-catalyzed transformation product of 13,14-dihydro-15-keto PGE2. 13,14-dihydro-15-keto PGE2 itself is a metabolite of PGE2 found in human plasma at a median level of 20-25 pg/ml.

Bicyclo PGE2 is a stable, base-catalyzed transformation product of 13,14-dihydro-15-keto PGE2. 13,14-dihydro-15-keto PGE2 itself is a metabolite of PGE2 found in human plasma at a median level of 20-25 pg/ml.

Bicyclo PGE2 is a stable, base-catalyzed transformation product of 13,14-dihydro-15-keto PGE2. 13,14-dihydro-15-keto PGE2 itself is a metabolite of PGE2 found in human plasma at a median level of 20-25 pg/ml.

An antibiotic produced by S. sapporonensis that inhibits Gram-negative bacteria, including E. coli, Klebsiella, Shigella, Salmonella, Citrobacter, E. cloacae, and the pathogenic group of Neisseria.

An antibiotic produced by S. sapporonensis that inhibits Gram-negative bacteria, including E. coli, Klebsiella, Shigella, Salmonella, Citrobacter, E. cloacae, and the pathogenic group of Neisseria.

A topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes, molds, yeasts, dimorphic fungi, and some Gram-positive bacteria a potent inhibitor of cytochrome P450 aromatase (Ki = 68 nM,

A topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes, molds, yeasts, dimorphic fungi, and some Gram-positive bacteria a potent inhibitor of cytochrome P450 aromatase (Ki = 68 nM,

A topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes, molds, yeasts, dimorphic fungi, and some Gram-positive bacteria a potent inhibitor of cytochrome P450 aromatase (Ki = 68 nM,

A topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes, molds, yeasts, dimorphic fungi, and some Gram-positive bacteria a potent inhibitor of cytochrome P450 aromatase (Ki = 68 nM,

A potent, selective, orally bioavailable inhibitor of Syk (IC₅₀ = 1 nM) blocks B cell receptor-mediated cell signaling and activation in whole blood (IC₅₀s = 0.27 and 0.

A potent, selective, orally bioavailable inhibitor of Syk (IC₅₀ = 1 nM) blocks B cell receptor-mediated cell signaling and activation in whole blood (IC₅₀s = 0.27 and 0.

A potent, selective, orally bioavailable inhibitor of Syk (IC₅₀ = 1 nM) blocks B cell receptor-mediated cell signaling and activation in whole blood (IC₅₀s = 0.27 and 0.