Biologically Active Small Molecules

A potent, selective, orally bioavailable inhibitor of Syk (IC₅₀ = 1 nM) blocks B cell receptor-mediated cell signaling and activation in whole blood (IC₅₀s = 0.27 and 0.

A potent, orally-available inhibitor of Hsp90 (Ki = 1.7 nM) that induces the degradation of oncoproteins, including HER2 (EC₅₀ = 38 nM), while up-regulating the expression of Hsp70 and Hsp27 cytotoxic to cancer cells and, when

A potent, orally-available inhibitor of Hsp90 (Ki = 1.7 nM) that induces the degradation of oncoproteins, including HER2 (EC₅₀ = 38 nM), while up-regulating the expression of Hsp70 and Hsp27 cytotoxic to cancer cells and, when

A potent, orally-available inhibitor of Hsp90 (Ki = 1.7 nM) that induces the degradation of oncoproteins, including HER2 (EC₅₀ = 38 nM), while up-regulating the expression of Hsp70 and Hsp27 cytotoxic to cancer cells and, when

A potent, orally-available inhibitor of Hsp90 (Ki = 1.7 nM) that induces the degradation of oncoproteins, including HER2 (EC₅₀ = 38 nM), while up-regulating the expression of Hsp70 and Hsp27 cytotoxic to cancer cells and, when

An inhibitor of several ASK isoforms when given at a concentration of 10 &microM, leaving residual kinase activity at less than 10% for ASK&alpha, &gamma, &epsilon, &zeta, &eta, &iota, and 20% for ASK&theta, without inhibiting isoforms

An inhibitor of several ASK isoforms when given at a concentration of 10 &microM, leaving residual kinase activity at less than 10% for ASK&alpha, &gamma, &epsilon, &zeta, &eta, &iota, and 20% for ASK&theta, without inhibiting isoforms

An inhibitor of several ASK isoforms when given at a concentration of 10 &microM, leaving residual kinase activity at less than 10% for ASK&alpha, &gamma, &epsilon, &zeta, &eta, &iota, and 20% for ASK&theta, without inhibiting isoforms

An inhibitor of several ASK isoforms when given at a concentration of 10 &microM, leaving residual kinase activity at less than 10% for ASK&alpha, &gamma, &epsilon, &zeta, &eta, &iota, and 20% for ASK&theta, without inhibiting isoforms

A stable, water-soluble ditaurate derivative of bilirubin meant to mimic endogenous bilirubin glucuronide derivatives exhibits anti-oxidant and antimutagenic effects.

A stable, water-soluble ditaurate derivative of bilirubin meant to mimic endogenous bilirubin glucuronide derivatives exhibits anti-oxidant and antimutagenic effects.

A stable, water-soluble ditaurate derivative of bilirubin meant to mimic endogenous bilirubin glucuronide derivatives exhibits anti-oxidant and antimutagenic effects.