Biologically Active Small Molecules

A potent inhibitor of MEK5 (IC₅₀ = 4.3 nM) and moderate inhibitor of ERK5 and TGF&betaR1 (IC₅₀s = 810 and 1800 nM, respectively).

A potent inhibitor of MEK5 (IC₅₀ = 4.3 nM) and moderate inhibitor of ERK5 and TGF&betaR1 (IC₅₀s = 810 and 1800 nM, respectively).

A potent inhibitor of both MEK5 and ERK5 (IC₅₀s = 1.5 and 59 nM, respectively) minimally inhibits a panel of related kinases, including MEK1/2 and ERK1/2 blocks sorbitol-induced phosphorylation of ERK5, without affecting phosphorylation

A potent inhibitor of both MEK5 and ERK5 (IC₅₀s = 1.5 and 59 nM, respectively) minimally inhibits a panel of related kinases, including MEK1/2 and ERK1/2 blocks sorbitol-induced phosphorylation of ERK5, without affecting phosphorylation

An LSD1 inhibitor.

An LSD1 inhibitor.

An LSD1 inhibitor.

Catch-relaxing peptide (CARP) is a peptide originally found in mollusks that exhibits neuromodulatory and cardiomodulatory activity. CARP decreases heart rate and modulates muscle contractility in vivo.

Catch-relaxing peptide (CARP) is a peptide originally found in mollusks that exhibits neuromodulatory and cardiomodulatory activity. CARP decreases heart rate and modulates muscle contractility in vivo.

Catch-relaxing peptide (CARP) is a peptide originally found in mollusks that exhibits neuromodulatory and cardiomodulatory activity. CARP decreases heart rate and modulates muscle contractility in vivo.

Bupivacaine is an amino amide anesthetic that decreases current amplitude and inhibits whole cell K+ currents in Ca2+-activated (BK/SK) K+ channels and N-type voltage-gated (Kv1/shaker and Kv3 KCNA/KCNC) K+ channels. Bupivacaine also inhibits

Bupivacaine is an amino amide anesthetic that decreases current amplitude and inhibits whole cell K+ currents in Ca2+-activated (BK/SK) K+ channels and N-type voltage-gated (Kv1/shaker and Kv3 KCNA/KCNC) K+ channels. Bupivacaine also inhibits