Biologically Active Small Molecules

An inhibitor of the Met kinase family (IC₅₀s = 1.8, 3.

An inhibitor of the Met kinase family (IC₅₀s = 1.8, 3.

An inhibitor of the Met kinase family (IC₅₀s = 1.8, 3.

An inhibitor of the Met kinase family (IC₅₀s = 1.8, 3.

A small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein (Kd = 21.1 nM Ki = 24.9 nM).

A small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein (Kd = 21.1 nM Ki = 24.9 nM).

A small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein (Kd = 21.1 nM Ki = 24.9 nM).

A cell-permeable, potent inhibitor of FABP4 (Ki is = 250 and 350 nM, respectively) reduces atherosclerosis in mice lacking ApoE and protects against the development of insulin resistance associated with genetic or diet-induced obesity in mice.

A cell-permeable, potent inhibitor of FABP4 (Ki is = 250 and 350 nM, respectively) reduces atherosclerosis in mice lacking ApoE and protects against the development of insulin resistance associated with genetic or diet-induced obesity in mice.

A cell-permeable, potent inhibitor of FABP4 (Ki is = 250 and 350 nM, respectively) reduces atherosclerosis in mice lacking ApoE and protects against the development of insulin resistance associated with genetic or diet-induced obesity in mice.

A cell-permeable, potent inhibitor of FABP4 (Ki is = 250 and 350 nM, respectively) reduces atherosclerosis in mice lacking ApoE and protects against the development of insulin resistance associated with genetic or diet-induced obesity in mice.

An irreversible inhibitor of BMX (IC₅₀ = 8 nM) and BTK (IC₅₀ = 10.4 nM) inhibits the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells (GI₅₀ = 25 nM), as well as RV-1, DU-145, PC-3, and VCAP prostate