Biologically Active Small Molecules

An irreversible inhibitor of BMX (IC₅₀ = 8 nM) and BTK (IC₅₀ = 10.4 nM) inhibits the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells (GI₅₀ = 25 nM), as well as RV-1, DU-145, PC-3, and VCAP prostate

An irreversible inhibitor of BMX (IC₅₀ = 8 nM) and BTK (IC₅₀ = 10.4 nM) inhibits the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells (GI₅₀ = 25 nM), as well as RV-1, DU-145, PC-3, and VCAP prostate

A synthetic intermediate useful for pharmaceutical synthesis.

A synthetic intermediate useful for pharmaceutical synthesis.

A cell-permeable, irreversible pan-caspase inhibitor contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor.

A cell-permeable, irreversible pan-caspase inhibitor contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor.

A cell-permeable, irreversible pan-caspase inhibitor contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor.

A NS3/4A protease inhibitor (Ki = 14 nM) that prevents HCV viral replication inhibits the NS3/4A protease in an in vitro HCV replicon system (EC₅₀ = 200 nM) and blocks the activity of recombinant HCV genotype 1a and 1b NS3/4A protease

A NS3/4A protease inhibitor (Ki = 14 nM) that prevents HCV viral replication inhibits the NS3/4A protease in an in vitro HCV replicon system (EC₅₀ = 200 nM) and blocks the activity of recombinant HCV genotype 1a and 1b NS3/4A protease

A NS3/4A protease inhibitor (Ki = 14 nM) that prevents HCV viral replication inhibits the NS3/4A protease in an in vitro HCV replicon system (EC₅₀ = 200 nM) and blocks the activity of recombinant HCV genotype 1a and 1b NS3/4A protease

A NS3/4A protease inhibitor (Ki = 14 nM) that prevents HCV viral replication inhibits the NS3/4A protease in an in vitro HCV replicon system (EC₅₀ = 200 nM) and blocks the activity of recombinant HCV genotype 1a and 1b NS3/4A protease

An aporphine alkaloid that possesses antioxidant and free-radical scavenging ability and has been linked to anti-inflammatory, anti-pyretic, anti-diabetic, anti-atherogenic, anti-platelet, anti-tumor, UV-protective, and hepatoprotective effects.