Biologically Active Small Molecules

An aporphine alkaloid that possesses antioxidant and free-radical scavenging ability and has been linked to anti-inflammatory, anti-pyretic, anti-diabetic, anti-atherogenic, anti-platelet, anti-tumor, UV-protective, and hepatoprotective effects.

Bombesin is a gastrin-releasing peptide analog that binds bombesin and GRP receptors. Derivatives of bombesin are currently under investigation as cancer imaging tools, as bombesin receptors are often overexpressed in tumor tissues.

Bombesin is a gastrin-releasing peptide analog that binds bombesin and GRP receptors. Derivatives of bombesin are currently under investigation as cancer imaging tools, as bombesin receptors are often overexpressed in tumor tissues.

Bombesin is a gastrin-releasing peptide analog that binds bombesin and GRP receptors. Derivatives of bombesin are currently under investigation as cancer imaging tools, as bombesin receptors are often overexpressed in tumor tissues.

A bacterial secondary metabolite which displays potent antiangiogenic activity, preventing tube formation in rat aorta explants (IC₅₀ = 0.8 nM) and inducing apoptosis in endothelial cells powerful inhibitor of both eukaryotic and

A bacterial secondary metabolite which displays potent antiangiogenic activity, preventing tube formation in rat aorta explants (IC₅₀ = 0.8 nM) and inducing apoptosis in endothelial cells powerful inhibitor of both eukaryotic and

A dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM) drives cell cycle arrest and apoptosis in cancer cell lines and has applications in multiple myeloma and certain lymphomas, as well as other types of

A dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM) drives cell cycle arrest and apoptosis in cancer cell lines and has applications in multiple myeloma and certain lymphomas, as well as other types of

A dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM) drives cell cycle arrest and apoptosis in cancer cell lines and has applications in multiple myeloma and certain lymphomas, as well as other types of

A dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM) drives cell cycle arrest and apoptosis in cancer cell lines and has applications in multiple myeloma and certain lymphomas, as well as other types of

An antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM) used, alone or in combination therapy, in the treatment of pulmonary arterial hypertension.

An antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM) used, alone or in combination therapy, in the treatment of pulmonary arterial hypertension.