Biologically Active Small Molecules

CAS Number: 2719-05-3 Synonyms: FH1 Methylenebis-4,4&#39-acetanilide NSC 12407 Molecular Formula: C₁₇H₁₈N₂O₂ Formula Weight: 282.3

CAS Number: 2719-05-3 Synonyms: FH1 Methylenebis-4,4&#39-acetanilide NSC 12407 Molecular Formula: C₁₇H₁₈N₂O₂ Formula Weight: 282.3

An inhibitor of ETV1 transcriptional activity that binds to ETV1 (KD = 17.1 &microM in vitro), which reduces p300-dependent acetylation and stability of ETV1 and, thereby, promotes its degradation dose-dependently prevents invasion of ETV1-reliant

An inhibitor of ETV1 transcriptional activity that binds to ETV1 (KD = 17.1 &microM in vitro), which reduces p300-dependent acetylation and stability of ETV1 and, thereby, promotes its degradation dose-dependently prevents invasion of ETV1-reliant

An inhibitor of ETV1 transcriptional activity that binds to ETV1 (KD = 17.1 &microM in vitro), which reduces p300-dependent acetylation and stability of ETV1 and, thereby, promotes its degradation dose-dependently prevents invasion of ETV1-reliant

An inhibitor of EHMT2, also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 &microM) induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis.

An inhibitor of EHMT2, also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 &microM) induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis.

An inhibitor of EHMT2, also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 &microM) induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis.

An inhibitor of EHMT2, also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 &microM) induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis.

An HDAC inhibitor (IC₅₀s = 29 nM, 62 nM, and 1.09 &microM for HDAC1, 2, and 3, respectively) possesses preferential binding kinetics with seven-fold longer half-life on HDAC2 compared to HDAC1 (143 min vs. 20 min).

An HDAC inhibitor (IC₅₀s = 29 nM, 62 nM, and 1.09 &microM for HDAC1, 2, and 3, respectively) possesses preferential binding kinetics with seven-fold longer half-life on HDAC2 compared to HDAC1 (143 min vs. 20 min).

An HDAC inhibitor (IC₅₀s = 29 nM, 62 nM, and 1.09 &microM for HDAC1, 2, and 3, respectively) possesses preferential binding kinetics with seven-fold longer half-life on HDAC2 compared to HDAC1 (143 min vs. 20 min).