Biologically Active Small Molecules

An HDAC inhibitor (IC₅₀s = 29 nM, 62 nM, and 1.09 &microM for HDAC1, 2, and 3, respectively) possesses preferential binding kinetics with seven-fold longer half-life on HDAC2 compared to HDAC1 (143 min vs. 20 min).

An HDAC inhibitor (IC₅₀s = 21 nM, 100 nM, and 11.48 &microM for HDAC1, 2, and 3, respectively) possesses six6-fold extended half-life for binding on HDAC2 compared to HDAC1 (381 min vs.

An HDAC inhibitor (IC₅₀s = 21 nM, 100 nM, and 11.48 &microM for HDAC1, 2, and 3, respectively) possesses six6-fold extended half-life for binding on HDAC2 compared to HDAC1 (381 min vs.

An HDAC inhibitor (IC₅₀s = 21 nM, 100 nM, and 11.48 &microM for HDAC1, 2, and 3, respectively) possesses six6-fold extended half-life for binding on HDAC2 compared to HDAC1 (381 min vs.

A small molecule inhibitor that potently and selectively inhibits both HDAC6 and HDAC8 (IC₅₀s = 36 and 120 nM, respectively).

A small molecule inhibitor that potently and selectively inhibits both HDAC6 and HDAC8 (IC₅₀s = 36 and 120 nM, respectively).

BRD7552 is a small molecule that induces expression of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD7552 dose-dependently increases PDX1 and insulin gene expression, as well as

BRD7552 is a small molecule that induces expression of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD7552 dose-dependently increases PDX1 and insulin gene expression, as well as

BRD7552 is a small molecule that induces expression of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD7552 dose-dependently increases PDX1 and insulin gene expression, as well as

BRD7552 is a small molecule that induces expression of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD7552 dose-dependently increases PDX1 and insulin gene expression, as well as

A natural fungal metabolite which reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum directly and reversibly inhibits Sec7 domain-containing GEFs which are necessary for Arf

A natural fungal metabolite which reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum directly and reversibly inhibits Sec7 domain-containing GEFs which are necessary for Arf