Biologically Active Small Molecules

A natural fungal metabolite which reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum directly and reversibly inhibits Sec7 domain-containing GEFs which are necessary for Arf

A neurotoxin that binds to voltage-gated sodium channels (IC₅₀ = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials

A dye which stains proteins in gels with ease and sensitivity used in the Bradford to quantify the amount of protein in a solution selectively inhibits P2X7 (IC₅₀s = 10.1 nM and 265 nM for rat and human P2X7, respectively) and reduces

A dye which stains proteins in gels with ease and sensitivity used in the Bradford to quantify the amount of protein in a solution selectively inhibits P2X7 (IC₅₀s = 10.1 nM and 265 nM for rat and human P2X7, respectively) and reduces

A selective &alpha2-adrenergic receptor agonist (Ki = 183 nM) that lowers intraocular pressure by decreasing aqueous humor synthesis and increasing drainage through uveoscleral outflow protects rat retinal ganglion cells against glutamate

A selective &alpha2-adrenergic receptor agonist (Ki = 183 nM) that lowers intraocular pressure by decreasing aqueous humor synthesis and increasing drainage through uveoscleral outflow protects rat retinal ganglion cells against glutamate

A selective &alpha2-adrenergic receptor agonist (Ki = 183 nM) that lowers intraocular pressure by decreasing aqueous humor synthesis and increasing drainage through uveoscleral outflow protects rat retinal ganglion cells against glutamate

A selective &alpha2-adrenergic receptor agonist (Ki = 183 nM) that lowers intraocular pressure by decreasing aqueous humor synthesis and increasing drainage through uveoscleral outflow protects rat retinal ganglion cells against glutamate

A potent inhibitor of carbonic anhydrases (IC50s = 3.2 and 45.3 nM for CAII and CAIV, respectively) that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion.

A potent inhibitor of carbonic anhydrases (IC50s = 3.2 and 45.3 nM for CAII and CAIV, respectively) that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion.

A potent inhibitor of carbonic anhydrases (IC50s = 3.2 and 45.3 nM for CAII and CAIV, respectively) that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion.

A potent inhibitor of carbonic anhydrases (IC50s = 3.2 and 45.3 nM for CAII and CAIV, respectively) that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion.