Biologically Active Small Molecules

An irreversible, noncompetitive inhibitor of PARP1 that disrupts binding between PARP1 and DNA by interacting with the DNA binding domain produces rapid apoptosis in the various cancer cell (IC50s = 40-128 &muM).

A low affinity calcium indicator (Kd = 7-26 &microM) with long excitation wavelengths (400/485 nm) that is suitable for detecting elevated calcium levels associated with activation of smooth muscle, neurons, and intracellular calcium stores.

A cell-permeant low affinity calcium indicator (Kd = ~7 uM) that exhibits a shift in excitation maximum from about 480 nm to 400 nm upon binding calcium, enabling ratiometric calcium measurements.

AVL-292 is a Bruton’s tyrosine kinase (BTK) inhibitor that exhibits anticancer chemotherapeutic activities. AVL-292 is in clinical development as a potential treatment for B-cell-related disorders such as chronic lymphocytic leukemia (CLL).

AVL-292 is a Bruton’s tyrosine kinase (BTK) inhibitor that exhibits anticancer chemotherapeutic activities. AVL-292 is in clinical development as a potential treatment for B-cell-related disorders such as chronic lymphocytic leukemia (CLL).

AVL-292 is a Bruton’s tyrosine kinase (BTK) inhibitor that exhibits anticancer chemotherapeutic activities. AVL-292 is in clinical development as a potential treatment for B-cell-related disorders such as chronic lymphocytic leukemia (CLL).

A cell-permeable, cyclic nucleotide derivative that mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor.

A cell-permeable, cyclic nucleotide derivative that mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor.

A cell-permeable, cyclic nucleotide derivative that mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor.

A cell-permeable, cyclic nucleotide derivative that mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor.

A glucocorticoid steroid that activates the glucorcorticoid receptor with an EC₅₀ value of 12.4 nM reduces inflammation and has utility in inflammatory diseases, like asthma and inflammatory bowel disease may be abused by athletes.

A glucocorticoid steroid that activates the glucorcorticoid receptor with an EC₅₀ value of 12.4 nM reduces inflammation and has utility in inflammatory diseases, like asthma and inflammatory bowel disease may be abused by athletes.