Biologically Active Small Molecules

A selective inhibitor of PI3K&alpha that is equipotent against both wild type and several mutant isoforms (IC₅₀s = 4.0-4.

A selective inhibitor of PI3K&alpha that is equipotent against both wild type and several mutant isoforms (IC₅₀s = 4.0-4.

An activator of the P2X receptors that exhibits 5-30-fold greater potency at the P2X7 receptor than ATP activates the human, rat, and mouse receptors with EC₅₀ values of 0.7, 3.6, and 285 &muM, respectively.

C-12 NBD ceramide is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity. It is hydrolyzed efficiently by alkaline ceramidase from P.

C-12 NBD ceramide is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity. It is hydrolyzed efficiently by alkaline ceramidase from P.

C-12 NBD ceramide is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity. It is hydrolyzed efficiently by alkaline ceramidase from P.

A fluorescent ceramide analog that contains a saturated bond in the C-4/C-5 position of the sphingosine backbone.

A fluorescent ceramide analog that contains a saturated bond in the C-4/C-5 position of the sphingosine backbone.

A fluorescent ceramide analog that contains a saturated bond in the C-4/C-5 position of the sphingosine backbone.

An endogenous ceramide, generated by ceramide synthase 6, that acts a lipid second messenger to regulate apoptosis and stress signaling.

An endogenous ceramide, generated by ceramide synthase 6, that acts a lipid second messenger to regulate apoptosis and stress signaling.

An endogenous ceramide, generated by ceramide synthase 6, that acts a lipid second messenger to regulate apoptosis and stress signaling.