Biologically Active Small Molecules

A cell permeable inhibitor of the PI3K catalytic subunit p110&delta (IC₅₀ = 2.5 nM) that demonstrates 40- to 300-fold selectivity against other PI3K class I enzymes (IC₅₀s = 820, 565, and 89 nM for p110&alpha, &beta, and

A cell permeable inhibitor of the PI3K catalytic subunit p110&delta (IC₅₀ = 2.5 nM) that demonstrates 40- to 300-fold selectivity against other PI3K class I enzymes (IC₅₀s = 820, 565, and 89 nM for p110&alpha, &beta, and

A cell permeable inhibitor of the PI3K catalytic subunit p110&delta (IC₅₀ = 2.5 nM) that demonstrates 40- to 300-fold selectivity against other PI3K class I enzymes (IC₅₀s = 820, 565, and 89 nM for p110&alpha, &beta, and

A cell-permeable dye that is cleaved by intracellular esterases, leaving membrane-impermeant calcein, a fluorescent indicator with absorption and emission maxima of 494 and 517 nm, respectively.

A cell-permeable dye that is cleaved by intracellular esterases, leaving membrane-impermeant calcein, a fluorescent indicator with absorption and emission maxima of 494 and 517 nm, respectively.

A xanthene commonly used for the fluorometric determination of calcium in solution can be used in assays that evaluate membrane integrity.

A xanthene commonly used for the fluorometric determination of calcium in solution can be used in assays that evaluate membrane integrity.

A xanthene commonly used for the fluorometric determination of calcium in solution can be used in assays that evaluate membrane integrity.

A xanthene commonly used for the fluorometric determination of calcium in solution can be used in assays that evaluate membrane integrity.

This peptide inhibits calcineurin phosphatase activity and is used to examine the effects of calcineurin in research studies. In cellular models, this peptide inhibits calcineurin-induced glutamate-mediated neuronal cell death and decreases L-type

This peptide inhibits calcineurin phosphatase activity and is used to examine the effects of calcineurin in research studies. In cellular models, this peptide inhibits calcineurin-induced glutamate-mediated neuronal cell death and decreases L-type

This peptide inhibits calcineurin phosphatase activity and is used to examine the effects of calcineurin in research studies. In cellular models, this peptide inhibits calcineurin-induced glutamate-mediated neuronal cell death and decreases L-type