Biologically Active Small Molecules

A cell permeable, peptide aldehyde inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM).

A cell permeable, peptide aldehyde inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM).

A cell permeable, peptide aldehyde inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM).

A cell permeable, selective inhibitor of &mu-calpain (calpain-1) and m-calpain (calpain-2) crosses the blood-brain barrier to inhibit brain cysteine protease activity reported to have protective effects in numerous rodent models of neurotrauma

A cell permeable, selective inhibitor of &mu-calpain (calpain-1) and m-calpain (calpain-2) crosses the blood-brain barrier to inhibit brain cysteine protease activity reported to have protective effects in numerous rodent models of neurotrauma

A cell permeable, selective inhibitor of &mu-calpain (calpain-1) and m-calpain (calpain-2) crosses the blood-brain barrier to inhibit brain cysteine protease activity reported to have protective effects in numerous rodent models of neurotrauma

A cell permeable, selective inhibitor of &mu-calpain (calpain-1) and m-calpain (calpain-2) crosses the blood-brain barrier to inhibit brain cysteine protease activity reported to have protective effects in numerous rodent models of neurotrauma

A reversible and selective inhibitor of calpain I (&mu-calpain, Ki = 19 nM), with lower affinities for calpain II (m-calpain, Ki = 120 nM) and cathepsin B (Ki = 750 nM).

A reversible and selective inhibitor of calpain I (&mu-calpain, Ki = 19 nM), with lower affinities for calpain II (m-calpain, Ki = 120 nM) and cathepsin B (Ki = 750 nM).

A reversible and selective inhibitor of calpain I (&mu-calpain, Ki = 19 nM), with lower affinities for calpain II (m-calpain, Ki = 120 nM) and cathepsin B (Ki = 750 nM).

A cell-penetrating peptide inhibitor of calpain (IC₅₀ = 5 nM) which completely abolishes calpain activity in platelets also a potent inhibitor of cathepsin K (IC₅₀ = 0.11 nM).

A cell-penetrating peptide inhibitor of calpain (IC₅₀ = 5 nM) which completely abolishes calpain activity in platelets also a potent inhibitor of cathepsin K (IC₅₀ = 0.11 nM).