Biologically Active Small Molecules

A cell-penetrating peptide inhibitor of calpain (IC₅₀ = 5 nM) which completely abolishes calpain activity in platelets also a potent inhibitor of cathepsin K (IC₅₀ = 0.11 nM).

A cell-penetrating peptide inhibitor of calpain (IC₅₀ = 5 nM) which completely abolishes calpain activity in platelets also a potent inhibitor of cathepsin K (IC₅₀ = 0.11 nM).

A specific PKC inhibitor (IC₅₀ = 50 nM versus an IC₅₀ &gt 50 &muM for PKA) whose activation depends on exposure to light also inhibits phospholipase D1 and D2 (IC₅₀s = 100 nM) demonstrates antitumor activity.

A specific PKC inhibitor (IC₅₀ = 50 nM versus an IC₅₀ &gt 50 &muM for PKA) whose activation depends on exposure to light also inhibits phospholipase D1 and D2 (IC₅₀s = 100 nM) demonstrates antitumor activity.

A trypsin-like protease inhibitor known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein, and thrombin used in the treatment of chronic pancreatitis and various manifestations of fibrosis.

A trypsin-like protease inhibitor known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein, and thrombin used in the treatment of chronic pancreatitis and various manifestations of fibrosis.

A trypsin-like protease inhibitor known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein, and thrombin used in the treatment of chronic pancreatitis and various manifestations of fibrosis.

A trypsin-like protease inhibitor known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein, and thrombin used in the treatment of chronic pancreatitis and various manifestations of fibrosis.

A cytotoxic, quinoline alkaloid that inhibits the DNA enzyme topoisomerase I (Top I) by binding the Top1-DNA cleavage complex and inducing DNA-strand breaks has strong anti-tumor activity and induces DNA damage at concentrations as low as 51 nM in

A cytotoxic, quinoline alkaloid that inhibits the DNA enzyme topoisomerase I (Top I) by binding the Top1-DNA cleavage complex and inducing DNA-strand breaks has strong anti-tumor activity and induces DNA damage at concentrations as low as 51 nM in

A cytotoxic, quinoline alkaloid that inhibits the DNA enzyme topoisomerase I (Top I) by binding the Top1-DNA cleavage complex and inducing DNA-strand breaks has strong anti-tumor activity and induces DNA damage at concentrations as low as 51 nM in

A cytotoxic, quinoline alkaloid that inhibits the DNA enzyme topoisomerase I (Top I) by binding the Top1-DNA cleavage complex and inducing DNA-strand breaks has strong anti-tumor activity and induces DNA damage at concentrations as low as 51 nM in