Biologically Active Small Molecules

A chalconoid with anti-inflammatory and anti-tumor activity suppresses NO and PGE2 synthesis, COX-2 expression, and NF-&kappaB signaling induces apoptosis in cancer cells.

A chalconoid with anti-inflammatory and anti-tumor activity suppresses NO and PGE2 synthesis, COX-2 expression, and NF-&kappaB signaling induces apoptosis in cancer cells.

A chalconoid with anti-inflammatory and anti-tumor activity suppresses NO and PGE2 synthesis, COX-2 expression, and NF-&kappaB signaling induces apoptosis in cancer cells.

Induces the differentiation of MHC-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 &microM.

Induces the differentiation of MHC-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 &microM.

Induces the differentiation of MHC-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 &microM.

Induces the differentiation of MHC-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 &microM.

An irreversible inhibitor of the chymotrypsin-like &beta5 subunit of the constitutive 20S proteasome (IC₅₀ = 5.2 nM) and the &beta5i subunit of the immunoproteasome 20Si (LMP7 IC₅₀ = 14 nM) with minimal cross reactivity to

An irreversible inhibitor of the chymotrypsin-like &beta5 subunit of the constitutive 20S proteasome (IC₅₀ = 5.2 nM) and the &beta5i subunit of the immunoproteasome 20Si (LMP7 IC₅₀ = 14 nM) with minimal cross reactivity to

An irreversible inhibitor of the chymotrypsin-like &beta5 subunit of the constitutive 20S proteasome (IC₅₀ = 5.2 nM) and the &beta5i subunit of the immunoproteasome 20Si (LMP7 IC₅₀ = 14 nM) with minimal cross reactivity to

A benzoylguanidine compound that selectively inhibits NHE-1 (IC₅₀s range from 0.03-3.4 &microM).

A benzoylguanidine compound that selectively inhibits NHE-1 (IC₅₀s range from 0.03-3.4 &microM).