Biologically Active Small Molecules

CAY10410 is an analog of PGD2/PGJ2 with structural modifications intended to give it PPAR&gamma ligand activity and resistance to metabolism. 15-deoxy-.

CAY10410 is an analog of PGD2/PGJ2 with structural modifications intended to give it PPAR&gamma ligand activity and resistance to metabolism. 15-deoxy-.

An analog of AEA with no intrinsic binding affinity for either CB1 or CB2 receptors potently inhibits AEA reuptake in U937 lymphoma cells (IC₅₀ = 3 &microM) may enhance endocannabinoid signalling by augmenting endocannabinoid

An analog of AEA with no intrinsic binding affinity for either CB1 or CB2 receptors potently inhibits AEA reuptake in U937 lymphoma cells (IC₅₀ = 3 &microM) may enhance endocannabinoid signalling by augmenting endocannabinoid

An analog of AEA with no intrinsic binding affinity for either CB1 or CB2 receptors potently inhibits AEA reuptake in U937 lymphoma cells (IC₅₀ = 3 &microM) may enhance endocannabinoid signalling by augmenting endocannabinoid

An analog of AEA with no intrinsic binding affinity for either CB1 or CB2 receptors potently inhibits AEA reuptake in U937 lymphoma cells (IC₅₀ = 3 &microM) may enhance endocannabinoid signalling by augmenting endocannabinoid

A potent, antidiabetic drug of the TZD structural class that lowers blood glucose leves in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKA&gamma mice at a dose of 100 mg/kg for four days increases the rate of insulin-stimulated

A potent, antidiabetic drug of the TZD structural class that lowers blood glucose leves in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKA&gamma mice at a dose of 100 mg/kg for four days increases the rate of insulin-stimulated

A potent, antidiabetic drug of the TZD structural class that lowers blood glucose leves in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKA&gamma mice at a dose of 100 mg/kg for four days increases the rate of insulin-stimulated

CAY10416 is a dual COX-2/5-LO inhibitor with IC₅₀ values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1.

CAY10416 is a dual COX-2/5-LO inhibitor with IC₅₀ values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1.

CAY10416 is a dual COX-2/5-LO inhibitor with IC₅₀ values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1.