Biologically Active Small Molecules

A selective inhibitor of the 20-HETE synthase, CYP4A11, exhibiting an IC50 values of 8.8 nM when tested in human renal microsomes.

A selective inhibitor of the 20-HETE synthase, CYP4A11, exhibiting an IC50 values of 8.8 nM when tested in human renal microsomes.

A selective inhibitor of the 20-HETE synthase, CYP4A11, exhibiting an IC50 values of 8.8 nM when tested in human renal microsomes.

A selective inhibitor of the 20-HETE synthase, CYP4A11, exhibiting an IC50 values of 8.8 nM when tested in human renal microsomes.

A selective, potent inhibitor of rat FAAH (Ki = 0.57 nM) exhibited IC50 values of 0.81, 83 nM, and 50 &microM for FAAH, TGH, and an uncharacterized hydrolase (KIAA1363), respectively, when screened against the serine hydrolase family of enzymes.

A selective, potent inhibitor of rat FAAH (Ki = 0.57 nM) exhibited IC50 values of 0.81, 83 nM, and 50 &microM for FAAH, TGH, and an uncharacterized hydrolase (KIAA1363), respectively, when screened against the serine hydrolase family of enzymes.

A selective, potent inhibitor of rat FAAH (Ki = 0.57 nM) exhibited IC50 values of 0.81, 83 nM, and 50 &microM for FAAH, TGH, and an uncharacterized hydrolase (KIAA1363), respectively, when screened against the serine hydrolase family of enzymes.

A selective, potent inhibitor of rat FAAH (Ki = 0.57 nM) exhibited IC50 values of 0.81, 83 nM, and 50 &microM for FAAH, TGH, and an uncharacterized hydrolase (KIAA1363), respectively, when screened against the serine hydrolase family of enzymes.

A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner inhibits the binding of tritiated

A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner inhibits the binding of tritiated

A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner inhibits the binding of tritiated

A pro-apoptotic activator of the apoptosome activates caspase-3 (EC50 = 5 &microM) in a cell free, multi-component assay.