Biologically Active Small Molecules

A pro-apoptotic activator of the apoptosome activates caspase-3 (EC50 = 5 &microM) in a cell free, multi-component assay.

A pro-apoptotic activator of the apoptosome activates caspase-3 (EC50 = 5 &microM) in a cell free, multi-component assay.

A pro-apoptotic activator of the apoptosome activates caspase-3 (EC50 = 5 &microM) in a cell free, multi-component assay.

A selective antagonist of S1P binding to the S1P3 receptor blocks calcium increase in HeLa cells by about 40% at 10 &microM.

A selective antagonist of S1P binding to the S1P3 receptor blocks calcium increase in HeLa cells by about 40% at 10 &microM.

A selective antagonist of S1P binding to the S1P3 receptor blocks calcium increase in HeLa cells by about 40% at 10 &microM.

A selective antagonist of S1P binding to the S1P3 receptor blocks calcium increase in HeLa cells by about 40% at 10 &microM.

An iodinated nonivamide, a potent TRPV1 antagonist with an IC50 value of approximately 10 nM.

An iodinated nonivamide, a potent TRPV1 antagonist with an IC50 value of approximately 10 nM.

An iodinated nonivamide, a potent TRPV1 antagonist with an IC50 value of approximately 10 nM.

An iodinated nonivamide, a potent TRPV1 antagonist with an IC50 value of approximately 10 nM.

A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner inhibits the binding of tritiated