Biologically Active Small Molecules

A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner inhibits the binding of tritiated

A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner inhibits the binding of tritiated

A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner inhibits the binding of tritiated

A celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM).

A celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM).

A celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM).

A celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM).

A labeled analog of AEA that is non-fluorescent when outside the cell but upon transport into the cell, is cleaved by esterases to give a bright fluorescence at 530 nm used as an alternative substrate to study AEA transport via the AEA transporter.

A labeled analog of AEA that is non-fluorescent when outside the cell but upon transport into the cell, is cleaved by esterases to give a bright fluorescence at 530 nm used as an alternative substrate to study AEA transport via the AEA transporter.

A labeled analog of AEA that is non-fluorescent when outside the cell but upon transport into the cell, is cleaved by esterases to give a bright fluorescence at 530 nm used as an alternative substrate to study AEA transport via the AEA transporter.

CAY10462 is the hydrochloride salt of CAY10434 and selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 of 8.8 nM when tested in human renal microsomes.

CAY10462 is the hydrochloride salt of CAY10434 and selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 of 8.8 nM when tested in human renal microsomes.