Biologically Active Small Molecules

Derivative of PGF1&alpha containing an acetylenic fluorobenzene substituent in the lower side chain binds to the recombinant human FP receptor with an IC50 value of about 0.5 &microM.

CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNF&alpha-induced activation of NF-&kappaB by CAY10512 is 0.

CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNF&alpha-induced activation of NF-&kappaB by CAY10512 is 0.

CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNF&alpha-induced activation of NF-&kappaB by CAY10512 is 0.

CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNF&alpha-induced activation of NF-&kappaB by CAY10512 is 0.

CAY10514 is an aromatic analog of 8(S)-HETE. It acts as a dual agonist of PPAR&alpha and PPAR&gamma with EC50 values of 0.173 and 0.642 &microM, respectively.

CAY10514 is an aromatic analog of 8(S)-HETE. It acts as a dual agonist of PPAR&alpha and PPAR&gamma with EC50 values of 0.173 and 0.642 &microM, respectively.

CAY10514 is an aromatic analog of 8(S)-HETE. It acts as a dual agonist of PPAR&alpha and PPAR&gamma with EC50 values of 0.173 and 0.642 &microM, respectively.

CAY10514 is an aromatic analog of 8(S)-HETE. It acts as a dual agonist of PPAR&alpha and PPAR&gamma with EC50 values of 0.173 and 0.642 &microM, respectively.

An inhibitor of PGE2 production through the selective modulation of mPGES-1 expression dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells (IC50 = 1.8 &microM) without affecting COX-2 expression.

An inhibitor of PGE2 production through the selective modulation of mPGES-1 expression dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells (IC50 = 1.8 &microM) without affecting COX-2 expression.

An inhibitor of PGE2 production through the selective modulation of mPGES-1 expression dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells (IC50 = 1.8 &microM) without affecting COX-2 expression.