Biologically Active Small Molecules

A TP receptor antagonist that shows ~20-fold selectivity for TP&beta (IC₅₀ = 99 nM) relative to TP&alpha (IC₅₀= 1,970 nM) in the inhibition of U-46619-mediated Ca2+ mobilization.

A TP receptor antagonist that shows ~20-fold selectivity for TP&beta (IC₅₀ = 99 nM) relative to TP&alpha (IC₅₀= 1,970 nM) in the inhibition of U-46619-mediated Ca2+ mobilization.

A TP receptor antagonist that shows ~20-fold selectivity for TP&beta (IC₅₀ = 99 nM) relative to TP&alpha (IC₅₀= 1,970 nM) in the inhibition of U-46619-mediated Ca2+ mobilization.

A TP receptor antagonist that shows ~20-fold selectivity for TP&beta (IC₅₀ = 99 nM) relative to TP&alpha (IC₅₀= 1,970 nM) in the inhibition of U-46619-mediated Ca2+ mobilization.

A potent antiprion compound that inhibits the accumulation of PrPc with an IC50 value of 3 nM in both ScN2a and F3 prion-infected mouse neuroblastoma cell lines also inhibits the formation of hydroxyl radicals in vitro with an IC50 value of 90

A potent antiprion compound that inhibits the accumulation of PrPc with an IC50 value of 3 nM in both ScN2a and F3 prion-infected mouse neuroblastoma cell lines also inhibits the formation of hydroxyl radicals in vitro with an IC50 value of 90

A potent antiprion compound that inhibits the accumulation of PrPc with an IC50 value of 3 nM in both ScN2a and F3 prion-infected mouse neuroblastoma cell lines also inhibits the formation of hydroxyl radicals in vitro with an IC50 value of 90

A potent antiprion compound that inhibits the accumulation of PrPc with an IC50 value of 3 nM in both ScN2a and F3 prion-infected mouse neuroblastoma cell lines also inhibits the formation of hydroxyl radicals in vitro with an IC50 value of 90

A potent inhibitor of Cdk5 and Cdk2, with IC50 values of 64 and 98 nM, respectively.

A potent inhibitor of Cdk5 and Cdk2, with IC50 values of 64 and 98 nM, respectively.

A potent inhibitor of Cdk5 and Cdk2, with IC50 values of 64 and 98 nM, respectively.

A potent inhibitor of Cdk5 and Cdk2, with IC50 values of 64 and 98 nM, respectively.