Biologically Active Small Molecules

A potent and selective inhibitor of CK2 with an IC50 value of 0.3 &microM and a Ki value of 0.2 &microM.

A potent and selective inhibitor of CK2 with an IC50 value of 0.3 &microM and a Ki value of 0.2 &microM.

A potent and selective inhibitor of CK2 with an IC50 value of 0.3 &microM and a Ki value of 0.2 &microM.

An 8-aza-9-oxo-15-hydroxy saturated analog of PGE2 selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and &gt3,000 nM, respectively) stimulates cAMP formation in excised mouse ovaries.

An 8-aza-9-oxo-15-hydroxy saturated analog of PGE2 selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and &gt3,000 nM, respectively) stimulates cAMP formation in excised mouse ovaries.

An 8-aza-9-oxo-15-hydroxy saturated analog of PGE2 selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and &gt3,000 nM, respectively) stimulates cAMP formation in excised mouse ovaries.

An 8-aza-9-oxo-15-hydroxy saturated analog of PGE2 selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and &gt3,000 nM, respectively) stimulates cAMP formation in excised mouse ovaries.

A naphthoquinone derivative that potently and reversibly inhibits indoleamine 2,3-dioxygenase (IC₅₀ = 55 nM) a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT).

A naphthoquinone derivative that potently and reversibly inhibits indoleamine 2,3-dioxygenase (IC₅₀ = 55 nM) a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT).

A naphthoquinone derivative that potently and reversibly inhibits indoleamine 2,3-dioxygenase (IC₅₀ = 55 nM) a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT).

A naphthoquinone derivative that potently and reversibly inhibits indoleamine 2,3-dioxygenase (IC₅₀ = 55 nM) a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT).

A potent, selective full agonist for BLT2 with an EC50 value of 20 nM activates BLT2 at significantly lower concentrations than LTB4 (EC50 = 170 nM) dose dependently increases intracellular calcium stores and induces ERK phosphorylation in CHO