Biologically Active Small Molecules

A potent, selective full agonist for BLT2 with an EC50 value of 20 nM activates BLT2 at significantly lower concentrations than LTB4 (EC50 = 170 nM) dose dependently increases intracellular calcium stores and induces ERK phosphorylation in CHO

A potent, selective full agonist for BLT2 with an EC50 value of 20 nM activates BLT2 at significantly lower concentrations than LTB4 (EC50 = 170 nM) dose dependently increases intracellular calcium stores and induces ERK phosphorylation in CHO

A potent, selective full agonist for BLT2 with an EC50 value of 20 nM activates BLT2 at significantly lower concentrations than LTB4 (EC50 = 170 nM) dose dependently increases intracellular calcium stores and induces ERK phosphorylation in CHO

A novel inhibitor of HIF-1a accumulation and gene transcriptional activity inhibits HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 &microM in human Hep3b and AGS cells, respectively.

A novel inhibitor of HIF-1a accumulation and gene transcriptional activity inhibits HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 &microM in human Hep3b and AGS cells, respectively.

A novel inhibitor of HIF-1a accumulation and gene transcriptional activity inhibits HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 &microM in human Hep3b and AGS cells, respectively.

A novel inhibitor of HIF-1a accumulation and gene transcriptional activity inhibits HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 &microM in human Hep3b and AGS cells, respectively.

A selective FFAR1 (GPR40) agonist (EC50 = 32nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41) increases glucose-stimulated insulin secretion at a concentration of 100 nM in the rat.

A selective FFAR1 (GPR40) agonist (EC50 = 32nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41) increases glucose-stimulated insulin secretion at a concentration of 100 nM in the rat.

A selective FFAR1 (GPR40) agonist (EC50 = 32nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41) increases glucose-stimulated insulin secretion at a concentration of 100 nM in the rat.

A selective FFAR1 (GPR40) agonist (EC50 = 32nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41) increases glucose-stimulated insulin secretion at a concentration of 100 nM in the rat.

A dual inhibitor of mPGES-1 (IC₅₀= 1.3 &muM) and 5-LO (IC₅₀ = 1.0 &muM) effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays.