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13281-10A very potent agonist of EP4, binding with a Ki value of 1.2 nM does not bind EP1, EP2, EP3, DP, FP, IP, or TP receptors.
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13281-5A very potent agonist of EP4, binding with a Ki value of 1.2 nM does not bind EP1, EP2, EP3, DP, FP, IP, or TP receptors.
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13281-500A very potent agonist of EP4, binding with a Ki value of 1.2 nM does not bind EP1, EP2, EP3, DP, FP, IP, or TP receptors.
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13282-1A PPAR&gamma agonist that is 4-fold more potent than rosiglitazone at the PPAR&gamma receptor demonstrating an EC50 value of 0.05 µM shows high selectivity for PPAR&gamma over PPAR&alpha (EC50 = 3.
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13282-10A PPAR&gamma agonist that is 4-fold more potent than rosiglitazone at the PPAR&gamma receptor demonstrating an EC50 value of 0.05 µM shows high selectivity for PPAR&gamma over PPAR&alpha (EC50 = 3.
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13282-5A PPAR&gamma agonist that is 4-fold more potent than rosiglitazone at the PPAR&gamma receptor demonstrating an EC50 value of 0.05 µM shows high selectivity for PPAR&gamma over PPAR&alpha (EC50 = 3.
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10009796-10Derived from HTS for compounds that increase the SIRT1-mediated deacetylation of a SIRT1-specific substrate dose-dependently suppresses the NF-&kappaB-dependent induction of TNF-&alpha by LPS in THP-1 cells, with approximately 75% inhibition
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10009796-100Derived from HTS for compounds that increase the SIRT1-mediated deacetylation of a SIRT1-specific substrate dose-dependently suppresses the NF-&kappaB-dependent induction of TNF-&alpha by LPS in THP-1 cells, with approximately 75% inhibition
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10009796-5Derived from HTS for compounds that increase the SIRT1-mediated deacetylation of a SIRT1-specific substrate dose-dependently suppresses the NF-&kappaB-dependent induction of TNF-&alpha by LPS in THP-1 cells, with approximately 75% inhibition
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10009796-50Derived from HTS for compounds that increase the SIRT1-mediated deacetylation of a SIRT1-specific substrate dose-dependently suppresses the NF-&kappaB-dependent induction of TNF-&alpha by LPS in THP-1 cells, with approximately 75% inhibition
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13146-1A potent and selective inhibitor of HDAC6 (IC<sub>50</sub> = 0.002 nM, as compared with 271, 252, 0.
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13146-10A potent and selective inhibitor of HDAC6 (IC<sub>50</sub> = 0.002 nM, as compared with 271, 252, 0.